Publications

2024

104. "Fluorescence-Based Monitoring of Early-Stage Aggregation of Amyloid-β, Amylin Peptide, Tau, and α-Synuclein Proteins" Y. Li, S. Awasthi*, L. Bryan, R. Ehrlich, N. Tonali, S. Balog, J. Yang, N. Sewald, M. Mayer* ACS Chem. Neurosci., 2024, 15, 3113-3123

103. "The dopamine analogue CA140 alleviates AD pathology, neuroinflammation, and rescues synaptic/cognitive functions by modulating DRD1 signaling or directly binding to Abeta" S. Chae, H. Lee, H. Lee, J. Kim, Y. J. Jeong, Y. Lin, H. Y. Kim, G. Leriche, R. S. Ehrlich, S. C. Lingl, M. Seo, Y. Lee, J. Yang*, J. Kim*, H. Hoe* J Neuroinflammation, 2024, 21, 200

102. "Reduction of hemagglutination induced by a SARS-CoV-2 spike protein fragment using an amyloid-binding benzothiazole amphiphile" M. Li, S. Castro Lingl, J. Yang* Sci. Rep., 2024, 14, 12317

101. "Excited State Rotational Freedom Impacts Viscosity Sensitivity in Arylcyanoamide Fluorescent Molecular Rotor Dyes" R. S. Ehrlich, S. Dasgupta, R. E. Jessup, K. L. Teppang, A. L. Shiao, K. Y. Jeoung, X. Su, A. Shivkumar, E. A. Theodorakis, F. Paesani, J. Yang* J. Phys Chem, B, 2024, 128, 16, 3946-3952

100. "Binding and Activation of LRP1-Dependent Cell Signaling in Schwann Cells Using a Peptide Derived from the Hemopexin Domain of MMP-9" J. H. Kim, A. Shivkumar, M. Norimoto, S. Castro Lingl, C. Seitz, R. E. Amaro, S. L. Gonias, J. Yang*, W. M. Campana* Biochemistry, 2024, 63, 6, 725-732

99. "Antivesiculation and Complete Unbinding of Tail-Tethered Lipids" K. Shih, G. Leriche, C. Liu, J. He, V. John, J. Fang, J. Barker, M. Nagao, L. Yang, J. Yang, M. Nieh* Langmuir, 2024, 40, 3, 1688-1697

2023

98. "Development of fluorophores for the detection of oligomeric aggregates of amyloidogenic proteins found in neurodegenerative diseases" K. Teppang, Q. Zhao, J. Yang* Front. Chem., 2023, 11, 1343118

97. "Fluorescently Labelled Tau Protein" S. Awasthi, L. Mummolo, Y. Li, L. Bryan, P. Nirmalraj, S. Balog, J. Yang, M. Mayer* Chimia, 2023, 77, 12

2022

96. "Site-Specific C-Terminal Fluorescent Labeling of Tau Protein" L. Bryan, S. Awasthi, Y. Li, P. N. Nirmalraj, S. Balog, J. Yang, M. Mayer* ACS Omega, 2022, 7, 47009–47014

95. "Noninvasive Antemortem Detection of Retinal Prions by a Fluorescent Tracer" P. Aguilar-Calvo, A. M. Sevillano, S. Rasool, K. J. Cao, L. M. Randolph, R. A. Rissman, S. T. Sarraf, J. Yang, C. J. Sigurdson* J Alzheimers D., 2022, 88, 1137-1145

94. "Artificial intelligence-rationalized balanced PPARα/γ dual agonism resets dysregulated macrophage processes in inflammatory bowel disease" G. D. Katkar, I. M. Sayed, M. S. Anandachar, V. Castillo, E. Vidales, D. Toobian, F. Usmani, J. R. Sawires, G. Leriche, J. Yang, W. J. Sandborn, S. Das*, D. Sahoo* & P. Ghosh* Communications Biology, 2022, 5, 231

2021

93. "Exploring the Effect of Aliphatic Substituents on Aryl Cyano Amides on Enhancement of Fluorescence upon Binding to Amyloid-β Aggregates" R. S. Ehrlich, A. L. Shiao, M. Li, K. L. Teppang, K. Y. Jeoung, E. A. Theodorakis, J. Yang* ACS Chem. Neurosci., 2021, 12, 2946-2952

92. "Tuning the Diameter, Stability, and Membrane Affinity of Peptide Pores by DNA-Programmed Self-Assembly" A. Fennouri, J. List, J. Ducrey, J. Dupasquier, V. Sukyte, S. F. Mayer, R. D. Vargas, L. Pascual Fernandez, F. Bertani, S. Rodriguez Gonzalo, J. Yang, M. Mayer* ACS Nano., 2021, 15, 11263-11275

91. "ARCAM-1 Facilitates Fluorescence Detection of Amyloid-Containing Deposits in the Retina" K. J. Cao, J. H. Kim, H. Kroeger, P. M. Gaffney, J. H. Lin, C. J. Sigurdson, J. Yang* Transl. Vis. Sci. Technol., 2021, 10, 5

90. "A single-liposome assay that enables temperature-dependent measurement of proton permeability of extremophile-inspired lipid membranes" A. Guha, M. L. McGuire, G. Leriche, J. Yang, M. Mayer* BBA - Biomembranes, 2021, 1863, 183567

2020

89. "Method to discriminate amyloids using fluorescent probes" K. L. Teppang, R. S. Ehrlich, J. Yang* Methods in Enzymology, 2020, 639, 91-114

88. "Benzothiazole amphiphiles promote RasGRF1‐associated dendritic spine formation in human stem cell‐derived neurons" J. L. Cifelli, K. Berg, J. Yang* FEBS Open Bio, 2020, 10, 386-395

2019

87. "Fusion of Bipolar Tetraether Lipid Membranes Without Enhanced Leakage of Small Molecules" G. Leriche, D. Stengel, D. Onofrei, T. Koyanagi, G. P. Holland, and J. Yang* Sci. Rep., 2019, 9, 19359

86. "Targeting specific membranes with an azide derivative of the pore-forming peptide ceratotoxin A" S. F. Mayer, J. Ducrey, J. Dupasquier, L. Haeni, B. Rothen-Rutishauser, J. Yang, A. Fennouri*, and M. Mayer* BBA - Biomembranes, 2019, 1861, 183023

85. "Fluid surface coatings for solid-state nanopores: comparison of phospholipid bilayers and archaea-inspired lipid monolayers" O. Eggenberger, G. Leriche, T. Koyanagi, C. Ying, J. Houghtaling, T. Schroeder, J. Yang, J. Li, A.R. Hall, and M. Mayer* Nanotechnology, 2019, 30, 325504

84. “Entropic Effects Enable Life at Extreme Temperatures” Y.H. Kim, G. Leriche, K. Diraviyam, T. Koyanagi, K. Guo, D. Onofrei, J. Patterson, A. Guha, N. Gianneschi, G.P. Holland, M.K. Gilson, M. Mayer, D.Sept, and J. Yang* Science Adv., 2019, 5, eaaw4783

83. "Noncovalent, electrostatic interactions induce positively cooperative binding of small molecules to Alzheimer's and Parkinson's disease-related amyloids" J.L. Cifelli, C.C. Capule, and J. Yang* ACS Chem. Neurosci., 2019, 10, 991-995

2018

82. "Identification of Patients with Preeclampsia by Measuring Fluorescence of an Amyloid-Binding Aryl Cyano Amide in Human Urine Samples" J.P. Do, K.J. Cao, S. Wei, L.C. Laurent, M.M. Parast, and J. Yang* Anal. Chem., 2018, 90, 14316-14320

81. "The small molecule CA140 inhibits the neuroinflammatory response in wild-type mice and a mouse model of AD" J.Y. Lee, J.H. Nam, Y. Nam, H.Y. Nam, G. Yoon, E. Ko, S.B. Kim, M.R. Bautista, C.C. Capule, T. Koyanagi, G. Leriche, H.G. Choi, J. Yang, J. Kim* and H.S. Hoe* J. Neuroinflammation, 2018, 15, 286

80. "Translational Opportunities for Amyloid-Targeting Fluorophores ” K.J. Cao and J. Yang* Chem. Commun., 2018, 54, 9107-9118

79. “Water permeability and elastic properties of an archaea inspired lipid synthesized by click chemistry” G. Leriche, A. Manafirad, S. Nguyen, N. Bell, J.P. Patterson, S. Thayumanavan, J. Yang, A.D. Dinsmore, and N.C. Gianneschi* Chem. Mat., 2018, 30, 3618-3622

78. “Solvation-guided design of fluorescent probes for discrimination of amyloids” K.J. Cao, K.M. Elbel, J.L. Cifelli, J. Cierra, C.J. Sigurdson, F. Paesani, E.A. Theodorakis, and J. Yang* Sci. Rep., 2018, 8, 6950

77. “Frequency-based analysis of gramicidin A nanopores enable detection of small molecules with picomolar sensitivity” Y.H. Kim, L. Hang, J.L. Cifelli, D. Sept, M. Mayer, and J. Yang* Anal. Chem., 2018, 90, 1635-1642

2017

76. “An electric-eel-inspired soft power source from stacked hydrogels” T.B.H. Schroeder, A. Guha, A. Lamoureux, G. VanRenterghem, D. Sept, M. Shtein, J. Yang, and M. Mayer* Nature, 2017, 552, 214-218

75. “Evaluation of tetraether lipid-based liposomal carriers for encapsulation and retention of nucleoside-based drugs” V. Paolucci, G. Leriche, T. Koyanagi, and J. Yang* Bioorg. Med. Chem. Lett., 2017, 27, 4319-4322

74. “Natural Seminal Amyloids as Targets for Development of Synthetic Inhibitors of HIV Transmission” D.A. Sheik, S. Dewhurst, and J. Yang* Acc. Chem. Res., 2017, 50, 2159-2166

73. “Thiol-triggered release of intraliposomal content from liposomes made of extremophile-inspired tetra ether lipids” T. Koyanagi, J.L. Cifelli, G. Leriche, D. Onofrei, G.P. Holland, and J. Yang* Bioconj. Chem., 2017, 28, 2041-2045

72. “Hybrid Lipids Inspired by Extremophiles and Eukaryotes Afford Serum-Stable Membranes with Low Leakage” T. Koyanagi, K.J. Cao, G. Leriche, D. Onofrei, G.P. Holland, M. Mayer, D. Sept, and J. Yang* Chem.-Eur. J., 2017, 23, 6757-6762

71. “Hydrophobic Nanoparticles Reduce the β-Sheet Content of SEVI Amyloid Fibrils and Inhibit SEVI-Enhanced HIV Infectivity” D.A. Sheik, J.M. Chamberlain, L. Brooks, M. Clark, Y.H. Kim, G. Leriche, C.P. Kubiak, S. Dewhurst, and J. Yang* Langmuir, 2017, 33, 2596-2602

70. “Characterization of Drug Encapsulation and Retention in Archaea-Inspired Tetraether Liposomes” G. Leriche, J.L. Cifelli, K.C. Sibucao, J.P. Patterson, T. Koyanagi, N.C. Gianneschi, and J. Yang* Org. Biomol. Chem., 2017, 15, 2157-2162

69. “Amyloid-β Ion Channels in a Membrane Comprising Brain Total Lipid Extracts” J. Lee, Y.H. Kim, F.T. Arce, A.L. Gillman, H. Jang, B.L. Kagan, R. Nussinov, J. Yang, and R. Lal* ACS Chem. Neurosci., 2017, 8, 1348-1357

2016

68. “Effects of Transmembrane Tethers in Extremophile-Inspired Lipid Membranes on H+/OH- Flux at Room Temperature” T. Schroeder, G. Leriche, T. Koyanagi, M. Johnson, K. Haengel, O. Eggenberger, C. Wang, Y.H. Kim, K. Diraviyam, D. Sept, J. Yang, and M. Mayer* Biophys. J., 2016, 110, 2430-2440

67. “Effects of Headgroups on Small Ion Permeability Across Archaea-Inspired Tetraether Lipid Membranes” T. Koyanagi, G. Leriche, A. Yep, D.

Onofrei, G.P. Holland, M. Mayer, and J. Yang* Chem.-Eur. J., 2016, 22, 8074-8077

66. “Benzothiazole Amphiphiles Ameliorate Amyloid-beta Related Cell Toxicity and Oxidative Stress ” J.L. Cifelli, T.S. Chung, H. Liu, P. Prangkio, M. Mayer, and J. Yang* ACS Chem. Neurosci., 2016, 7, 682-688

65. “Benzothiazole Amphiphiles Promote the Formation of Dendritic Spines in Primary Hippocampal Neurons” J.L. Cifelli, L. Dozier, T.S. Chung, G.N. Patrick, and J. Yang* J. Biol. Chem., 2016, 291, 11981-11992

64. “Hexa (ethylene glycol) derivative of benzothiazole aniline promotes dendritic spine formation through the RasGRF-1-Ras dependent pathway” N. J. Lee, J.M. Song, H.-J. Cho, Y.M. Sung, T. Lee, A. Chung, S.-H. Hong, J.L. Cifelli, M. Rubinshtein, L.K. Habib, C.C. Capule, R.S. Turner, D.T.S. Pak, J. Yang, H.-S. Hoe* BBA-Molecular Basis of Disease, 2016, 1862, 284-295

63. “Cyclohexane Rings Reduce Membrane Permeability to Small Ions in Archaea-Inspired Tetraether Lipids” T. Koyanagi, G. Leriche, D. Onofrei, G.P. Holland, M. Mayer, and J. Yang* Angew. Chem., Int. Ed., 2016, 55, 1890-1893

62. “A Fluorescent Analog of Batimastat Enables Imaging of α-Secretase in Living Cells” G. Leriche, A.C. Chen, S. Kim, D.J. Selkoe, and J. Yang* ACS Chem. Neurosci., 2016, 7, 40-45

61. “Dual Responsive Polymeric Nanoparticles Prepared by Direct Functionalization of Polylactic Acid-Based Polymers via Graft-From Ring Opening Metathesis Polymerization” K.M. Veccharelli, V.K. Tong, J.L. Young, J. Yang,* and N.C. Gianneschi* Chem. Commun., 2016, 52, 567-570

2015

60. “Real-Time Monitoring of Alzheimer’s-Related Amyloid Aggregation via Probe Enhancement-Fluorescence Correlation Spectroscopy” Y. Guan, K.J. Cao, A. Cantlon, K. Elbel, E.A. Theodorakis, D.M. Walsh, J. Yang,* and J.V. Shah* ACS Chem. Neurosci., 2015, 6, 1503-1508

59. “Spontaneous Reconstitution of Functional Transmembrane Proteins During Bioorthogonal Phospholipid Membrane Synthesis” C.M. Cole, R.J. Brea, Y.H. Kim, M.D. Hardy, J. Yang, and N.K. Devaraj* Angew. Chem., Int. Ed., 2015, 54, 12738-12742

58. “Inhibition of the Enhancement of Infection of Human Immunodeficency Virus by Semen-Derived Enhancer of Virus Infection Using Amyloid-Targeting Polymeric Nanoparticles” D.A, Sheik, L. Brooks, K. Frantzen, S. Dewhurst, and J. Yang* ACS Nano, 2015, 9, 1829-1836

2014

57. “Development of a Folate Receptor (FR)-Targeted Indenoisoquinoline Using a pH-Sensitive N-Ethoxybenzylimidazole (NEBI) Bifunctional Cross-Linker” Y. Cao and J. Yang* Bioconj. Chem., 2014, 25, 873-878

56. “A tetra(ethylene glycol) derivative of benzothiazole aniline ameliorates dendritic spine density and cognitive function in a mouse model for Alzheimer’s disease” J.M. Song, A.M. DiBattista, Y.M. Sung, J.M. Ahn, R.S. Turner, J. Yang, D.T.S. Pak, H.-K. Lee, H.-S. Hoe* Exp. Neurol., 2014, 252, 105-113

2013

55. “Engineered Ion Channels as Emerging Tools for Chemical Biology” M. Mayer* and J. Yang* Acc. Chem. Res., 2013, 46, 2998-3008

54. “A Model for the Interfacial Kinetics of Phospholipase D Activity on Long-Chain Lipids” S. Majd, E.C. Yusko, J. Yang, D. Sept, and M. Mayer* Biophys. J., 2013, 105 , 146-153

53. “A tetra(ethylene glycol) derivative of benzothiazole aniline enhances Ras mediated spinogenesis” A. Megill, T. Lee, A. DiBattista, J. M. Song, M. Spitzer, M. Rubinshtein, L.K. Habib, C.C. Capule, M. Mayer, R. Turner, A. Kirkwood, J. Yang, D. Pak, H.-K. Lee,* and H.-S. Hoe* J. Neurosci., 2013, 33, 9306-9318

2012

52. “Multivariate Analyses of Amyloid-β Oligomer Populations Indicate a Connection between Pore Formation and Cytotoxicity” P. Prangkio, E.C. Yusko, D. Sept, J. Yang, and M. Mayer* PLoS One, 2012, 7, e47261

51. “Amino Naphthalenyl-2-Cyano-Acrylate (ANCA) Probes Fluorescently Discriminate between Amyloid-β and Prion Plaques in Brain” K. Cao, M. Farahi, M. Dakanali, W.M. Chang, C.J. Sigurdson, E.A. Theodorakis,* and J. Yang* J. Am. Chem. Soc., 2012, 134, 17338-17341

50. “Stimuli-Responsive Drug Delivery Systems” J. Yang* Adv. Drug Deliv. Rev., 2012, 64, 965-966

49. “An ELISA-based Method to Quantify the Association of Small Molecules with Aggregated Amyloid Peptides” C.C. Capule and J. Yang* Anal. Chem., 2012, 84, 1786-1791

48. “Oligovalent Amyloid-Binding Agents Reduce SEVI-Mediated Enhancement of HIV-1 Infection” C.C. Capule, C. Brown, J.S. Olsen, S. Dewhurst,* and J. Yang* J. Am Chem. Soc., 2012, 134, 905-908

2011

47. “Self-assembled, cation-selective ion channels from an oligo(ethylene glycol) derivative of benzothiazole aniline” P. Prangkio, D.K. Rao, K.D. Lance, M. Rubinshtein, J. Yang, and M. Mayer* BBA-Biomembranes, 2011, 1808, 2877-2885

46. “Using Charge to Control the Functional Properties of Self-Assembled Nanopores in Membranes” M.X. Macrae, D. Schlamadinger, J.E. Kim, M. Mayer,* and J. Yang* Small, 2011, 7, 2016-2020

45. “ANCA: A Family of Fluorescent Probes that Bind and Stain Amyloid Plaques in Human Tissue ” W.M. Chang, M. Dakanali, C.C. Capule, C.J. Sigurdson, J. Yang,* and E.A. Theodorakis* ACS Chem. Neurosci., 2011, 2, 249-255

44. “Design, Synthesis and Structure-Activity Relationship (SAR) Studies of 2,4-Disubstituted Pyrimidine Derivatives: Dual Activity as Cholinesterase and Abeta-Aggregation Inhibitors” T. Mohamed, X. Zhao, L.K. Habib, J. Yang, and P.P.N. Rao* Bioorg. Med. Chem., 2011, 19, 2269-2281

43. “Controlling the translocation of proteins through nanopores with bioinspired fluid walls” E.C. Yusko, J.M. Johnson, S. Majd, P. Prangkio, R.C. Rollings, J. Li, J. Yang,* and M. Mayer* Nature Nanotech., 2011, 6, 253-260

2001-2010

42. “Inhibitors of Catalase-Amyloid Interactions Protect Cells from beta-Amyloid Induced Oxidative Stress and Toxicity” L.K. Habib, M.T.C. Lee, and J. Yang* J. Biol. Chem., 2010, 285, 38933-38943

41. “Amyloid Binding Small Molecules Efficiently Block SEVI and Semen Mediated Enhancement of HIV-1 Infection” J.S. Olsen, C. Brown, C.C. Capule, M. Rubinshtein, T.M. Doran, R.K. Srivastava, C. Feng, B.L. Nilsson, J. Yang, and S. Dewhurst* J. Biol. Chem., 2010, 285, 35488-35496

40. “Amyloid-beta peptide is a substrate of the human 20S proteasome” X. Zhao and J. Yang* ACS Chem. Neurosci., 2010, 1, 655-660

39. “pH-Sensitive, N-Ethoxybenzylimidazole (NEBI) Bifunctional Crosslinkers Enable Triggered Release of Therapeutics from Drug Delivery Carriers” A. Luong, T. Issarapanichkit, S.D. Kong, R. Fong, and J. Yang* Org. Biomol. Chem., 2010, 8, 5105-5109

38. “Mechanistic Insight into Gramicidin-based Detection of Protein-Ligand Interactions via Sensitized Photoinactivation” T.I. Rokitskaya, M.X. Macrae, S. Blake, N.S. Egorova, E.A. Kotova, J. Yang,* and Y.N. Antonenko* J. Phys.: Condens. Matter, 2010, 22, 454118

37. “Facile procedure for generating sidechain functionalized poly(alpha-hydroxy acid) copolymers from aldehydes via a versatile Passerini-type condensation” M. Rubinshtein, C.R. James, J.L. Young, Y.J. Ma, Y. Kobayashi, N. Gianneschi,* and J. Yang* Org. Lett., 2010, 12, 3560-3563

36. “Nanopore Recordings to Quantify Activity-Related Properties of Proteins” E.C. Yusko, Y.N. Billeh, J. Yang, and M. Mayer. Book chapter in Nanopores: Sensing Fundamental Biological Interactions at the Single Molecule Level Ed. I. Samir and R. Bashir, Springer Publishing Company, 2010

35. “Applications of Biological Pores in Nanomedicine, Sensing, and Nanoelectronics” S. Majd, E.C. Yusko, Y.N. Billeh, M.X. Macrae, J. Yang, and M. Mayer Curr. Opin. Biotechnol. 2010, 21, 439-476

34. “Nanoscale Ionic Diodes with Tunable and Switchable Rectifying Behavior” M.X. Macrae, S. Blake, M. Mayer,* and J. Yang* J. Am. Chem. Soc. 2010, 132, 1766-1767

33. “Rational Design of Amyloid Binding Agents Based on the Molecular Rotor Motif” J. Sutharsan, M. Dakanali, C.C. Capule, M.A. Haidekker, J. Yang,* and E.A. Theodorakis* ChemMedChem 2010, 5, 56-60

32. “A Semi-Synthetic Ion Channel Platform for Detection of Phosphatase and Protease Activity” M.X. Macrae, S. Blake, X. Jiang, R. Capone, D. J. Estes, M. Mayer,* and J. Yang* ACS Nano 2009, 3, 3567-3580

31. “Gramicidin Pores Report the Activity of Membrane-Active Enzymes” S. Majd, E.C. Yusko, A.D. Macbriar, J. Yang,* and M. Mayer* J. Am. Chem. Soc. 2009, 131, 16119-16126

30. “Reactive Derivatives of Gramicidin Enable Light- and Ion-Modulated Ion Channels” M.X. Macrae, S. Blake, T. Mayer, M. Mayer,* and J. Yang* Proc. SPIE 2009, 7397, 739709-01-739709-13

29. “A Non-chromatographic Method for the Purification of a Bivalently Active Monoclonal IgG Antibody from Biological Fluids” B. Bilgicer, S. Thomas, B. Shaw, G. Kaufman, V. Krishnamurthy, L. Estroff, J. Yang, and G.M. Whitesides* J. Am. Chem. Soc. 2009, 131, 9361-9367

28. “Amyloid-beta Induced Ion Flux in Artificial Lipid Bilayers and Neuronal Cells: Resolving a Controversy” R. Capone, P. Prangkio, A. M. Sauer, M. R. Bautista, R. S. Turner, J. Yang,* and M. Mayer* Neurotox. Res. 2009, 16, 1-13

27. “Chemically Reactive Derivatives of Gramicidin A for Developing Ion Channel-Based Nanoprobes” S. Blake, R. Capone, M. Mayer,* and J. Yang* Bioconjugate Chem. 2008, 19, 1614-1624

26. “Assay to Screen for Molecules that Associate with Alzheimer’s Related b-Amyloid Fibrils” P. Inbar, M. R. Bautista, S. A. Takayama, and J. Yang* Anal. Chem., 2008, 80, 3502-3506

25. “Using Ion Channel-Forming Peptides to Quantify Protein-Ligand Interactions” M. Mayer, V. Semetey, I. Gitlin, J. Yang, and G.M. Whitesides* J. Am. Chem. Soc., 2008, 130, 1453-1465

24. “Designing Nanosensors based on Charged Derivatives of Gramicidin A” R. Capone, S. Blake, M. R. Restrepo, J. Yang,* and M. Mayer* J. Am. Chem. Soc., 2007, 129, 9737-9745

23. “Acidic Hydrolysis of N-ethoxybenzylimidazoles: Potential Applications as pH-Sensitive Linkers for Drug Delivery” S.D. Kong, A. Luong, G. Manorek, S.B. Howell, and J. Yang* Bioconjugate Chem., 2007, 18, 293-296

22. “Oligo(ethylene glycol) Derivatives of Thioflavin T as Inhibitors of Protein-Amyloid Interactions” P. Inbar, C. Q. Li, S. A. Takayama, M. R. Bautista, J. Yang* ChemBioChem, 2006, 7, 1563-1566

21. “Monitoring Chemical Reaction Using Ion Channel-Forming Peptides” S. Blake, T. Mayer, M. Mayer,* and J. Yang* ChemBioChem, 2006, 7(3), 433-435

20. “Inhibiting Protein-Amyloid Interactions with Small Molecules: A Surface Chemistry Approach” P. Inbar and J. Yang* Bioorg. Med. Chem. Lett., 2006, 16, 1076-1079

19. “A Bacterial Printing Press that Regenerates its Ink: Contact Printing Bacteria Using Hydrogel Stamps” D.B. Weibel, A. Lee, M. Mayer, S.F. Brady, J. Yang, W. DiLuzio, and G.M. Whitesides* Langmuir, 2005, 21, 6436-6442

18. “Eliminating Positive Charges on the Surface of Carbonic Anhydrase has no Significant Influence on Folding from Sodium Dodecyl Sulfate” K. L. Guidiksen, I. Gitlin, J. Yang, A. R. Urbach, and G. M. Whitesides* J. Am. Chem. Soc., 2005, 127, 4707-4714

17. “The influence of the Zn(II) cofactor on the refolding of Bovine Carbonic Anhydrase after Denaturation with SDS” K. L. Guidiksen, A. R. Urbach, I. Gitlin, J. Yang, J. A. Vazquez, C. E. Costello, and G. M. Whitesides* Anal. Chem., 2004, 76, 7151-7161

16. “Self-Assembled Aggregates of IgGs as Templates for the Growth of Clusters of Gold Nanoparticles” J. Yang,* M. Mayer, J.K. Kriebel, P. Parstecki, and G.M. Whitesides* Angew. Chem. Int. Ed., 2004, 43, 1555-1558

15. “Micropatterned Agarose Gels for Stamping Arrays of Proteins and Gradients of Proteins” M. Mayer, J. Yang, I. Gitlin, D. Gracias, and G.M. Whitesides* Proteomics, 2004, 4, 2366-2376

14. “Synthesis of Monodisperse Polymers from Proteins” J. Yang, I. Gitlin, V.M. Krishnamurthy, J.A. Vazquez, C.E. Costello, and G.M. Whitesides* J. Am. Chem. Soc., 2003, 125, 12392-12393

13. “The Redox Properties of Cytochrome c Adsorbed on Self-Assembled Monolayers: A probe for Protein Conformation and Orientation” X. Chen, R. Ferrigno, J. Yang, and G. M. Whitesides* Langmuir, 2002, 18, 7009-7015

12. “Massively Parallel Adhesion and Reactivity Measurements Using a Simple and Inexpensive Magnetic Tweezers” F. Assi, R. Jenks, J. Yang, C. Love, and M. Prentiss* J. Appl. Phys., 2002, 92, 5584-5586

11. “Fabrication of Frequency Selective Surfaces Using Microlens Photolithography” M.-H. Wu, K. E. Paul, J. Yang, and G. M. Whitesides* Appl. Phys. Lett., 2002, 80, 3500-3502

10. “Catalytic Oxidations of Steroid Substrates by Artificial Cytochrome P-450 Enzymes” J. Yang, B. Gabriele, S. Belvedere, Y. Huang and R. Breslow* J. Org. Chem., 2002, 67, 5057-5067

9. “Facile Synthesis of beta-Cyclodextrin Dithiols” J. Yang* and D. K. Leung Bioorg. & Med. Chem. Lett., 2002, 12, 169-170

8. “Biomimetic Hydroxylation of Saturated Carbons with Artificial Cytochrome P-450 Enzymes—Liberating Chemistry from the Tyranny of Functional Groups” R. Breslow*, J. Yang, and J. Yan Tetrahedron, 2002, 58, 653-659

1996-2000

7. “The hydroxylation and amidation of equilenin acetate catalyzed by chloro[5, 10, 15, 20-tetrakis(pentafluorophenyl)porphyrinato]manganese (III)” J. Yang, R. Weinberg, and R. Breslow* Chem. Comm., 2000, 531-532

6. “Selective Hydroxylation of a Steroid at C-9 by an Artificial Cytochrome P-450” J. Yang and R. Breslow* Angew. Chem., 2000, 112, 2804-2806; Angew.. Chem., Int. Ed., 2000, 39, 2692-2695

5. “Regioselective Oxidations of Equilenin Derivatives Catalyzed by a Rhodium (III) Porphyrin Complex- Contrast with the Manganese (III) Porphyrin” J. Yang and R. Breslow* Tet. Lett. 2000, 41, 8063-8067

4. “Geometrically directed steroid hydroxylation with high turnover by a fluorinated cytochrome P-450” R. Breslow*, B. Gabriele, and J. Yang Tet. Lett. 1998, 39, 2887-2890

3. “An artificial cytochrome P-450 that hydroxylates unactivated carbons with regio- and stereoselectivity and useful catalytic turnovers” R. Breslow*, Y. Huang, X. Zhang, and J. Yang Proc. Nat. Acad. Sci. USA, 1997, 94, 11156-11158

2. “Spontaneous fission properties of 262Rf” M. R. Lane, K. E. Gregorich, D. M. Lee, M. F. Mohar, M. Hsu, C.D. Katcher, B. Kadkhodayan, M. P. Neu, N. J. Stoyer, E.R. Sylwester, J. C. Yang, D. C. Hoffman* Phys. Rev. C, 1996, 53 v.6, 2893-2899

1. “Chemical studies of Rutherfordium (element 104). 2. Solvent extraction into tributylphosphate from HBr solutions” C. D. Katcher, K. E. Gregorich, D. M. Lee, Y. Watanabe, B. Kadkhodayan, B. Wierczinski, M. R. Lane, E. R. Sylwester, D. A. Keeney, M. Hendricks, N. J. Stoyer, J. Yang, M. Hsu, D. C. Hoffman*, A. Bilewicz Radiochimica Acta, 1996, 75:3, 127-133

Patents:

33. "Catechol amide compound regulating neuroinflammatory response" H.-S. Hoe, J. Nam, J. Lee, and J. Yang: Korean provisional patent filed on 06/2018

32. “Cognitive Function” J. Yang, H.-S. Hoe, and R.S. Turner: US Patent filed on 02/2017

31. "Benzothiazole Amphiphiles" J. Yang: US Patent filed on 01/2017

30. “Reduced Membrane Permeability from Novel Tetraether Lipids” J. Yang, T. Koyanagi, G. Leriche, M. Mayer: US Patent filed on 08/2016

29. “Probe for Detection of Amyloidogenic Protein Aggregates by Probe-Enhanced Fluorescence Correlation Spectroscopy” J. Yang, J.V. Shah, and D.M. Walsh: US Patent filed on 07/2016

28. "Benzothiazole Amphiphiles" J. Yang: Provisional patent filed on 01/2016

27. “Reduced Membrane Permeability from Novel Tetraether Lipids” J. Yang, T. Koyanagi, G. Leriche, M. Mayer: Provisional patent filed on 08/2015

26. “Probe for Detection of Amyloidogenic Protein Aggregates by Probe-Enhanced Fluorescence Correlation Spectroscopy” J. Yang, J.V. Shah, and D.M. Walsh: Provisional patent filed on 07/2015 (62/188,198)

25. “Amyloid-Targeting Agents and Methods of Using the Same” J. Yang, E. Theodorakis, and S. Sarraf: US Patent filed on 03/2015

US Patent issued on 06/2018 (10,005,745)

24. “Novel Amyloid-Targeting Agents” J. Yang, E. Theodorakis, and S. Sarraf: Provisional patent filed on 03/2014 (61/955,366)

23. “Novel Compounds that Improve Memory and Learning” J. Yang, H.-S. Hoe, and R.S. Turner: US Patent filed on 02/2014

22. “Novel Compounds that Improve Memory and Learning” J. Yang, H.-S. Hoe, and R.S. Turner: Provisional patent filed on 02/2013

21. “Controlling Translocation Through Nanopores with Fluid Walls” M. Mayer, E. Yusko, and J. Yang: US Patent filed on 02/2012 (13/400,472)

US Patent issued on 05/2016 (9,347,929)

20. “Reducing Transmission of Sexually Transmitted Infections” J. Yang, C.C. Capule, and S. Dewhurst: Provisional patent filed on 11/2011

19. “Reducing Transmission of Sexually Transmitted Infections” S. Dewhurst, J.S.T. Olsen, B. Nilsson, and J. Yang: US Patent filed on 04/2011 (61/327,461)

18. “Controlling Translocation Through Nanopores with Fluid Walls” M. Mayer, E. Yusko, and J. Yang: Provisional patent filed on 03/2011 (61/448,093)

17. “Amyloid Binding Agents” J. Yang and E. Theodorakis: US Patent filed on 12/2010

US Patent #1 issued on 01/2015 (8,940,918)

US Patent #2 issued on 01/2017 (9,551,722)

16. “Fibril-Targeting Microbicides for Protection Against Sexually Transmissible Microbial Pathogens Present in Semen, including HIV” S. Dewhurst, J.S.T. Olsen, and J. Yang: Provisional patent filed on 04/2010

15. “Design and Identification of Novel Amyloid Binding Agents” J. Yang and E. Theodorakis: Provisional patent filed on 12/2009

14. “Targeted Enediynes for Selective Degradation of Aggregated beta-Amyloid Peptides” J. Yang and M. Rubinshtein: Provisional patent filed on 07/2008

13. “Novel Ion Channel-Forming Peptides” J. Yang, S. Blake, and M. Mayer: US Patent filed on 07/2008

US Patent issued on 11/2013 (8,586,369)

12. “Screening Assays for Inhibitors of Amyloid-beta Peptide Ion Channel Formation” M. Mayer and J. Yang: US Patent filed on 05/2008 (08/006,885)

11. Small molecules that target aggregated beta-amyloid as diagnostics and/or therapeutics for Alzheimer’s Disease” J. Yang, P. Inbar, M.R. Bautista, and M. Mayer: US Patent filed on 05/2008 (08/065,410)

10. “Novel Ion Channel-Forming Peptides” J. Yang and S. Blake: Provisional patent filed on 07/2007 (60/948,689)

9. “Screening Assays for Inhibitors of Amyloid-beta Peptide Ion Channel Formation” M. Mayer and J. Yang: Provisional patent filed on 05/2007 (60/932,293)

8. “Small molecules that target aggregated beta-amyloid as diagnostics and/or therapeutics for Alzheimer’s Disease” J. Yang, P. Inbar, M.R. Bautista, and M. Mayer: Provisional patent filed on 05/2007 (60/940,869)

7. “Acid-Sensitive Linkers for Drug Delivery” J. Yang, S.D. Kong, A. Luong, and S. B. Howell: US Patent filed on 04/2007 (07/008,499)

US patent issued on 11/2013 (8,575,359)

6. “Compounds and Methods for the Diagnosis and Treatment of Amyloid Associated Diseases” J. Yang and P. Inbar: US Patent filed on 07/2006 (11/487,224)

US patent #1 issued on 02/2010 (7,666,866)

US patent #2 issued on 06/2014 (8,741,833)

5. “New pH-Sensitive Linkers for Drug Delivery” J. Yang and S.D. Kong: Provisional patent filed on 04/2006 (60/789,014)

4. “Compounds and Methods for the Diagnosis and Treatment of Alzheimer’s Disease” J. Yang and P. Inbar: Provisional patent filed on 12/2005 (60/699,726)

3. “New approach for therapeutics for Alzheimer’s Disease” J. Yang, and P. Inbar: Provisional patent filed on 07/2005 (60/750,422)

2. R. Breslow, J. Yang, and B. Gabriele

European Patent issued in 1999 (wo1999051644)

1. “Catalyst that oxidizes steroids and other substrates with catalytic turnover” R. Breslow, J. Yang, and B. Gabriele

U.S. Patent issued on 08/2000 (6,103,892)